Bone marrow stem cells

How it works

Bone marrow functions as the nursery where all our blood cells come from. Within this tissue, are multiple types of stem cells, but the mesenchymal stem cell, or MSC, has the most promise as an agent of healing. The MSC is a potent cell which can transform into ligament, cartilage or bone, depending on its surrounding environment. The mesenchymal stem cell also produces an anti-inflammatory effect and signals other nearby cells to regenerate. 

Our unique preparation

Bone marrow is usually obtained from the iliac crest area of the pelvis using a special needle. Fluoroscopy is used to ensure correct needle placement.  The marrow is then concentrated in a special centrifuge to yield bone marrow aspirate concentrate (BMAC). 

Pain relief from a BMAC procedure is not only because of the stem cells, but also because of a very potent concentration of anti-inflammatory cytokines present within the BMAC itself.  Cytokines are small proteins released by cells. They have a specific effect on the interactions and communications between cells. They are often either pro-inflammatory or anti-inflammatory in nature. Our special processing of the bone marrow to create BMAC results in the anti-inflammatory cytokines being in a much larger concentration than the pro-inflammatory cytokines. 

Mesenchymal Stem Cells

How it works

One of the more common stem cells found in the bone marrow and fat tissue is the mesenchymal stem cell (MSC) which can give rise to muscle, ligaments, cartilage and is a potent force causing new blood vessel formation. These cells  also have powerful anti-inflammatory, healing,  and pain modulating effects. Mesenchymal stem cells are typically obtained from either your own bone marrow or fat.  At Sierra Stem Cell Institute,  we have extensive experience with both methods.

MSC's function as singaling cells which communicate with nearby tissues to promote healing.  They do this by secreting cytokines, which are specific cell signal proteins.  MSC's also secrete micro-RNA which can "reprogram" local injured tissues to promote regeneration.  

While no statements can be made regarding the curative affect any specific orthopedic or musculoskeletal condition using these stem cell procedures, many patients report significant lessening of symptoms. We are happy to share patient results — while maintaining patient confidentiality — upon request.